The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Jul. 07, 2010
Young Lag Cho, Daejeon, KR;
Jong Un Cho, Daejeon, KR;
Sung Yoon Baek, Daejeon, KR;
Ho Young Song, Daejeon, KR;
Tae Kyo Park, Daejeon, KR;
Sung Ho Woo, Daejeon, KR;
Yong Zu Kim, Daejeon, KR;
Young Lag Cho, Daejeon, KR;
Jong Un Cho, Daejeon, KR;
Sung Yoon Baek, Daejeon, KR;
Ho Young Song, Daejeon, KR;
Tae Kyo Park, Daejeon, KR;
Sung Ho Woo, Daejeon, KR;
Yong Zu Kim, Daejeon, KR;
Legochem Bioscience Ltd., Daejeon, KR;
Abstract
Provided is a method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors, and said method using 1-fluoro-4-nitrobenzen as a starting material. According to the method of the present invention, (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors can be prepared in a high purity and a high yield.