The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Feb. 17, 2012
Chanchal Sadhu, Bothell, WA (US);
Ken Dick, Bothell, WA (US);
Jennifer Treiberg, Redmond, WA (US);
C. Gregory Sowell, Mukilteo, WA (US);
Edward A. Kesicki, Bothell, WA (US);
Amy Oliver, Bothell, WA (US);
Chanchal Sadhu, Bothell, WA (US);
Ken Dick, Bothell, WA (US);
Jennifer Treiberg, Redmond, WA (US);
C. Gregory Sowell, Mukilteo, WA (US);
Edward A. Kesicki, Bothell, WA (US);
Amy Oliver, Bothell, WA (US);
ICOS Corporation, Indianapolis, IN (US);
Abstract
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.