The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Jul. 13, 2010
Mikitomo Yasutake, Tokyo, JP;
Kasumi Ninomiya, Tokyo, JP;
Junichi Honda, Tokyo, JP;
Atsushi Ochiai, Chiba, JP;
Chisako Yamauchi, Chiba, JP;
Mikitomo Yasutake, Tokyo, JP;
Kasumi Ninomiya, Tokyo, JP;
Junichi Honda, Tokyo, JP;
Atsushi Ochiai, Chiba, JP;
Chisako Yamauchi, Chiba, JP;
Asahi Kasei Medical Co., Ltd., Tokyo, JP;
National Cancer Center, Tokyo, JP;
Abstract
It is an object of the present invention to provide a novel method for decreasing the number of clinical cases for which trastuzumab administration is ineffective. The present invention provides a method for treating a living individual with epithelial cancer comprising: step (a) of selectively reducing KLRG1-positive immunocytes in the peripheral blood of a living individual with epithelial cancer ex vivo, which is positive for a cancer-specific membrane antigen expressed in epithelial cancer cells and positive for a KLRG1 ligand; and step (b) of administering, to the living individual, a therapeutic agent for cancer comprising an antibody reacting with the cancer-specific membrane antigen expressed in epithelial cancer cells and having antibody-dependent cell cytotoxicity.