The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Mar. 23, 2012
John R. Mascola, Rockville, MD (US);
Richard T. Wyatt, San Diego, CA (US);
Xueling Wu, Potomac, MD (US);
Yuxing LI, Boyds, MD (US);
Carl-magnus Hogerkorp, Vellinge, SE;
Mario Roederer, Washington, DC (US);
Zhi-yong Yang, Potomac, MD (US);
Gary J. Nabel, Washington, DC (US);
Peter D. Kwong, Washington, DC (US);
Tongqing Zhou, Boyds, MD (US);
Mark Connors, Bethesda, MD (US);
William R. Schief, Encinitas, CA (US);
John R. Mascola, Rockville, MD (US);
Richard T. Wyatt, San Diego, CA (US);
Xueling Wu, Potomac, MD (US);
Yuxing Li, Boyds, MD (US);
Carl-Magnus Hogerkorp, Vellinge, SE;
Mario Roederer, Washington, DC (US);
Zhi-yong Yang, Potomac, MD (US);
Gary J. Nabel, Washington, DC (US);
Peter D. Kwong, Washington, DC (US);
Tongqing Zhou, Boyds, MD (US);
Mark Connors, Bethesda, MD (US);
William R. Schief, Encinitas, CA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
University of Washington, Seattle, WA (US);
Abstract
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.