The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Sep. 12, 2012
LI Long, Hercules, CA (US);
Asha Yabannavar, Lafayette, CA (US);
Isabel Zaror, El Cerrito, CA (US);
Sang Hoon Lee, Palo Alto, CA (US);
Deborah Hurst, Piedmont, CA (US);
Li Long, Hercules, CA (US);
Mohammad Luqman, Danville, CA (US);
Asha Yabannavar, Lafayette, CA (US);
Isabel Zaror, El Cerrito, CA (US);
Sang Hoon Lee, Palo Alto, CA (US);
Deborah Hurst, Piedmont, CA (US);
Novartis Vaccines and Diagnostics, Inc., Emeryville, CA (US);
Abstract
Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.