The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Jun. 09, 2010
Lavinia Diana Cicortas Gunnarsson, Oslo, NO;
Didrik Paus, Oslo, NO;
Jenny Margareta Karlsson, Oslo, NO;
Remko Albert Griep, Slemmestad, NO;
Sergej Michailovic Kiprijanov, Oslo, NO;
Lavinia Diana Cicortas Gunnarsson, Oslo, NO;
Didrik Paus, Oslo, NO;
Jenny Margareta Karlsson, Oslo, NO;
Remko Albert Griep, Slemmestad, NO;
Sergej Michailovic Kiprijanov, Oslo, NO;
Affitech Research AS, Oslo, NO;
Abstract
Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided.