The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Mar. 21, 2012
Yang Liu, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Guo-yun Chen, Ann Arbor, MI (US);
Xincheng Zheng, Ann Arbor, MI (US);
Xi Cheng, Woodland, CA (US);
Steve Kunkel, Ann Arbor, MI (US);
Yang Liu, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Guo-Yun Chen, Ann Arbor, MI (US);
Xincheng Zheng, Ann Arbor, MI (US);
Xi Cheng, Woodland, CA (US);
Steve Kunkel, Ann Arbor, MI (US);
The Regents of The University of Michigan, Ann Arbor, MI (US);
Abstract
The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.