The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2014
Filed:
Sep. 12, 2012
Daniel J. Coady, San Jose, CA (US);
Richard A. Dipietro, Campbell, CA (US);
Amanda C. Engler, San Jose, CA (US);
James L. Hedrick, Pleasanton, CA (US);
Ashlynn L. Lee, Singapore, SG;
Shrinivas Venkataraman, Singapore, SG;
Yi Yan Yang, Singapore, SG;
Daniel J. Coady, San Jose, CA (US);
Richard A. DiPietro, Campbell, CA (US);
Amanda C. Engler, San Jose, CA (US);
James L. Hedrick, Pleasanton, CA (US);
Ashlynn L. Lee, Singapore, SG;
Shrinivas Venkataraman, Singapore, SG;
Yi Yan Yang, Singapore, SG;
International Business Machines Corporation, Armonk, NY (US);
Agency for Science, Technology and Research, Singapore, SG;
Abstract
A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.