The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2014
Filed:
Mar. 19, 2012
Gilles Clermont, Fombell, PA (US);
Patricia A. Hebda, Sarver, PA (US);
Yee Key LI, Pittsburgh, PA (US);
Qi MI, Pittsburgh, PA (US);
David L. Steed, Pittsburgh, PA (US);
Joshua Thomas Sullivan, Butler, PA (US);
Katherine Verdolini Abbott, Cheswick, PA (US);
Yoram Vodovotz, Sewickley, PA (US);
Ivan Petrov Yotov, Pittsburgh, PA (US);
Gary an, Chicago, IL (US);
Gilles Clermont, Fombell, PA (US);
Patricia A. Hebda, Sarver, PA (US);
Yee Key Li, Pittsburgh, PA (US);
Qi Mi, Pittsburgh, PA (US);
David L. Steed, Pittsburgh, PA (US);
Joshua Thomas Sullivan, Butler, PA (US);
Katherine Verdolini Abbott, Cheswick, PA (US);
Yoram Vodovotz, Sewickley, PA (US);
Ivan Petrov Yotov, Pittsburgh, PA (US);
Gary An, Chicago, IL (US);
University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.