The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2014
Filed:
Mar. 09, 2012
Yuuichi Sugimoto, Tokyo, JP;
Kouichi Uoto, Tokyo, JP;
Takanori Wakabayashi, Tokyo, JP;
Masaki Miyazaki, Chiba, JP;
Masaki Setoguchi, Tokyo, JP;
Toru Taniguchi, Tokyo, JP;
Keisuke Yoshida, Tokyo, JP;
Akitake Yamaguchi, Tokyo, JP;
Shoko Yoshida, Chiba, JP;
Yuuichi Sugimoto, Tokyo, JP;
Kouichi Uoto, Tokyo, JP;
Takanori Wakabayashi, Tokyo, JP;
Masaki Miyazaki, Chiba, JP;
Masaki Setoguchi, Tokyo, JP;
Toru Taniguchi, Tokyo, JP;
Keisuke Yoshida, Tokyo, JP;
Akitake Yamaguchi, Tokyo, JP;
Shoko Yoshida, Chiba, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R, R, R, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.