The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2014
Filed:
Apr. 28, 2011
Applicants:
Saswati Chatterjee, Altadena, CA (US);
Laura Smith, Pasadena, CA (US);
Kamehameha Wong, Altadena, CA (US);
Inventors:
Saswati Chatterjee, Altadena, CA (US);
Laura Smith, Pasadena, CA (US);
Kamehameha Wong, Altadena, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C07K 14/075 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
Novel adeno-associated virus (AAV) isolates in nucleotide and amino acid forms and uses thereof are provided. The isolates show tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Discrete modified portions of the cap gene, VP1, VP2, and VP3, may be used alone or in combination in the present methods.