The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2014
Filed:
Feb. 27, 2007
Hans Jürgen Wester, Ilmmünster, DE;
Norman Koglin, Berlin, DE;
Markus Schwaiger, München, DE;
Horst Kessler, Garching, DE;
Burkhardt Laufer, München, DE;
Oliver Demmer, München, DE;
Martina Anton, Vaterstetten, DE;
Hans Jürgen Wester, Ilmmünster, DE;
Norman Koglin, Berlin, DE;
Markus Schwaiger, München, DE;
Horst Kessler, Garching, DE;
Burkhardt Laufer, München, DE;
Oliver Demmer, München, DE;
Martina Anton, Vaterstetten, DE;
Technische Universitat Munchen, Hazelwood, MO (US);
Abstract
Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as ICin the presence ofI-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N-methyl derivative of a basic amino acid.