The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2014
Filed:
Aug. 09, 2010
Hua Bai, Zhejiang, CN;
Xuyang Zhao, Sichuan, CN;
Xiaojie Xu, Zhejiang, CN;
Xiaoyu Liu, Zhejiang, CN;
Yuncai Zhang, Zhejiang, CN;
Ying Chen, Sichuan, CN;
Xiaohe Zheng, Zhejiang, CN;
Maojian Gu, Shanghai, CN;
Qifeng Zhu, Zhejiang, CN;
Yong Zhang, Zhejiang, CN;
Hairong Luo, Zhejiang, CN;
Hua Bai, Zhejiang, CN;
Xuyang Zhao, Sichuan, CN;
Xiaojie Xu, Zhejiang, CN;
Xiaoyu Liu, Zhejiang, CN;
Yuncai Zhang, Zhejiang, CN;
Ying Chen, Sichuan, CN;
Xiaohe Zheng, Zhejiang, CN;
Maojian Gu, Shanghai, CN;
Qifeng Zhu, Zhejiang, CN;
Yong Zhang, Zhejiang, CN;
Hairong Luo, Zhejiang, CN;
Abstract
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R, R, R, R, Rand Rare defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.