The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2014
Filed:
Jun. 13, 2011
Daniel M. Sullivan, Tampa, FL (US);
Joel G. Turner, Tampa, FL (US);
Thomas C. Rowe, Gainesville, FL (US);
David A. Ostrov, Gainesville, FL (US);
Daniel M. Sullivan, Tampa, FL (US);
Joel G. Turner, Tampa, FL (US);
Thomas C. Rowe, Gainesville, FL (US);
David A. Ostrov, Gainesville, FL (US);
H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Abstract
A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty small molecule inhibitors (SMI) that bind to the two nuclear export sequences (NES) topo IIα have been identified from the NCI database using computer-generated molecular modeling. These SMI will improve the effectiveness of topo II directed therapeutics, particularly in the treatment of diseases such as multiple myeloma (MM). In vitro apoptosis assays indicate that these drugs may be effective as single agents or in combination with currently used cancer drugs that target topo II.