The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2014
Filed:
Oct. 22, 2010
Jung Tae Lee, Daejeon, KR;
Kyung Duk Moon, Daejeon, KR;
Ji Yong Yoon, Daejeon, KR;
Byung Je Sung, Daejeon, KR;
Dong Heon Lee, Daejeon, KR;
Dong Eun Lee, Busan, KR;
Su Yeon Ryu, Daejeon, KR;
Hyun BO Shim, Seoul, KR;
Kyung Jae Kang, Seoul, KR;
Jung Tae Lee, Daejeon, KR;
Kyung Duk Moon, Daejeon, KR;
Ji Yong Yoon, Daejeon, KR;
Byung Je Sung, Daejeon, KR;
Dong Heon Lee, Daejeon, KR;
Dong Eun Lee, Busan, KR;
Su Yeon Ryu, Daejeon, KR;
Hyun Bo Shim, Seoul, KR;
Kyung Jae Kang, Seoul, KR;
Hanwha Chemical Corporation, , KR;
Abstract
The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.