The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Jul. 31, 2012
George G. Wu, Basking Ridge, NJ (US);
Anantha Sudhakar, Fremont, CA (US);
Tao Wang, Springfield, NJ (US);
Ji Xie, Edison, NJ (US);
Frank X. Chen, Plainsboro, NJ (US);
Marc Poirier, Stewartsville, NJ (US);
Mingsheng Huang, Plainsboro, NJ (US);
Vijay Sabesan, Millbrae, CA (US);
Daw-long Kwok, Gillette, NJ (US);
Jian Cui, Edison, NJ (US);
Xiaojing Yang, Waterford, CT (US);
Tiruvettipuram K. Thiruvengadam, Kendall Park, NJ (US);
Jing Liao, Edison, NJ (US);
Illia Zavialov, Princeton, NJ (US);
Hoa N. Nguyen, Dayton, NJ (US);
Ngiap Kie Lim, Somerset, NJ (US);
George G. Wu, Basking Ridge, NJ (US);
Anantha Sudhakar, Fremont, CA (US);
Tao Wang, Springfield, NJ (US);
Ji Xie, Edison, NJ (US);
Frank X. Chen, Plainsboro, NJ (US);
Marc Poirier, Stewartsville, NJ (US);
Mingsheng Huang, Plainsboro, NJ (US);
Vijay Sabesan, Millbrae, CA (US);
Daw-long Kwok, Gillette, NJ (US);
Jian Cui, Edison, NJ (US);
Xiaojing Yang, Waterford, CT (US);
Tiruvettipuram K. Thiruvengadam, Kendall Park, NJ (US);
Jing Liao, Edison, NJ (US);
Illia Zavialov, Princeton, NJ (US);
Hoa N. Nguyen, Dayton, NJ (US);
Ngiap Kie Lim, Somerset, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: