The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Nov. 09, 2010
Applicants:
Jeffrey V. Ravetch, New York, NY (US);
Rene G. Ott, Vienna, AT;
Inventors:
Jeffrey V. Ravetch, New York, NY (US);
Rene G. Ott, Vienna, AT;
Assignee:
The Rockefeller University, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides reagents, methods and systems for predicting the inhibitory activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is less than one (1).