The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Jul. 15, 2008
Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
Thavalakulamgara K. Sasikumar, Edison, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Theodros Asberom, West Orange, NJ (US);
Wen-lian Wu, Edison, NJ (US);
Hongmei LI, Warren, NJ (US);
Ruo Xu, Watchung, NJ (US);
Hubert B. Josien, Jersey City, NJ (US);
Thavalakulamgara K. Sasikumar, Edison, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Theodros Asberom, West Orange, NJ (US);
Wen-Lian Wu, Edison, NJ (US);
Hongmei Li, Warren, NJ (US);
Ruo Xu, Watchung, NJ (US);
Hubert B. Josien, Jersey City, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L, n, X, Ar, Y, Z, Q, and Qare as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.