The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Dec. 08, 2010
Susan P Perrine, Weston, MA (US);
Douglas V Faller, Weston, MA (US);
Ronald J Berenson, Mercer Island, WA (US);
Susan P Perrine, Weston, MA (US);
Douglas V Faller, Weston, MA (US);
Ronald J Berenson, Mercer Island, WA (US);
Trustees of Boston University, Boston, MA (US);
Hemaquest Pharmaceuticals, Inc., Seattle, WA (US);
Abstract
Disclosed herein are methods and low dose regimens for increasing fetal hemoglobin levels in patients with red blood cell disorders, such as beta thalassemia, sickle cell disease, other anemias, or blood loss. Fetal and total hemoglobin levels and red blood cell counts are increased by administering 2,2-dimethylbutyrate (DMB) alone or in combination with hydroxyurea, decitabine or an HDAC inhibitor. Treatment can be continued for at least two weeks.