The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
May. 03, 2012
Edward John Belouski, Camarillo, CA (US);
Murielle Marie Ellison, Thousand Oaks, CA (US);
Agnes Eva Hamburger, Newbury Park, CA (US);
Randy Ira Hecht, Thousand Oaks, CA (US);
Yue-sheng LI, Thousand Oaks, CA (US);
Mark Leo Michaels, Encino, CA (US);
Jeonghoon Sun, Thousand Oaks, CA (US);
Jing Xu, Thousand Oaks, CA (US);
Edward John Belouski, Camarillo, CA (US);
Murielle Marie Ellison, Thousand Oaks, CA (US);
Agnes Eva Hamburger, Newbury Park, CA (US);
Randy Ira Hecht, Thousand Oaks, CA (US);
Yue-Sheng Li, Thousand Oaks, CA (US);
Mark Leo Michaels, Encino, CA (US);
Jeonghoon Sun, Thousand Oaks, CA (US);
Jing Xu, Thousand Oaks, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The invention provides a multimer comprising at least a first and a second chain, the first chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine; the proline at position 171 is substituted with glycine; and the alanine at position 180 is substituted with glutamic acid; a linker sequence comprising SEQ ID NO:31; and an Fe domain comprising SEQ NO:11; and a second chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine; the proline at position 171 is substituted with glycine; and the alanine at position 180 is substituted with glutamic acid; a linker sequence comprising SEQ ID NO:31; and an Fe domain comprising SEQ ID NO:11, nucleic acids encoding the multimer, pharmaceutical compositions comprising the multimer and methods for treating metabolic disorders using such nucleic acids, multimers or pharmaceutical compositions.