The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Jul. 23, 2010
Applicants:
Shouguang Jin, Gainesville, FL (US);
Candace Bichsel, Gainesville, FL (US);
Inventors:
Shouguang Jin, Gainesville, FL (US);
Candace Bichsel, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
A modifiedtype III secretion system has been developed that efficiently delivers selected proteins into a host cell. In one example, a functional nuclear Cre Recombinase is injected into embryonic stem (ES) cells and can be used to induce pluripotent stem (iPS) cells. This method of in vitro lineage directed differentiation prevents insertional mutagenesis and provides a route to selected stem cell renewal and cell-based therapies.