The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 31, 2013
Filed:
Oct. 12, 2006
Yen-ming Hsu, Lexington, MA (US);
Leonid Gorelik, Quincy, MA (US);
Tatiana Novobrantseva, Wellesley, MA (US);
Joanne Quan, San Francisco, CA (US);
Flavius Martin, Hayward, CA (US);
Susan L. Kalled, Concord, MA (US);
Yen-Ming Hsu, Lexington, MA (US);
Leonid Gorelik, Quincy, MA (US);
Tatiana Novobrantseva, Wellesley, MA (US);
Joanne Quan, San Francisco, CA (US);
Flavius Martin, Hayward, CA (US);
Susan L. Kalled, Concord, MA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
BAFF plays a central role in acquired immunity. The disclosure identifies BAFF-responsive genes that are substantially upregulated by administration of BAFF and substantially downregulated by treatment with a BAFF antagonist. Specific genes are: NF-κB2, CD23, H2-Mβ (the beta chain of H2-DM), Fig-1, and OBF-1. The disclosure provides methods and compositions for: monitoring the activity of a BAFF antagonist in a mammal; monitoring BAFF activity in a mammal; identifying a mammal to be treated with a BAFF antagonist; and related uses. Such methods include detecting one or more molecules selected from the group consisting of Fig-1 molecule, OBF-1 molecule, and H2-Mβ molecule in a biological sample of the mammal, and optionally further detecting NF-κB2 molecule and/or CD23 molecule in the biological sample.