The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 31, 2013

Filed:

Sep. 27, 2010
Applicants:

Pierre Zoldhelyi, Houston, TX (US);

James T. Willerson, Houston, TX (US);

Qui Liu, Houston, TX (US);

Zhi-qiang Chen, Houston, TX (US);

Inventors:

Pierre Zoldhelyi, Houston, TX (US);

James T. Willerson, Houston, TX (US);

Qui Liu, Houston, TX (US);

Zhi-Qiang Chen, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2006.01); C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
Abstract

Compositions containing an effective amount of mesodermal-like multipotent mammalian mononuclear cells that express both CD34 and M-cadherin cell surface markers are used for preventing, treating or reducing the severity of tissue ischemia or an ischemia associated disorder in a mammal. Such uses may include repopulating an in vivo site with new myocytes and/or vascularizing an ischemic or adjacent tissue. Detection of the level and/or distribution of CD34/M-cadherinmesodermal-like precursor cells in a mammalian tissue sample is used to diagnose, among other things, whether transplantation of autologous CD34/M-cadherinmesodermal-like precursor cells to an ischemic site is indicated.


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