The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2013
Filed:
Sep. 07, 2010
Xungui He, Shanghai, CN;
Jianping Guo, Shanghai, CN;
Yanling Wang, Shanghai, CN;
Wensheng Tang, Shanghai, CN;
Xingzhong Zhang, Shanghai, CN;
Xuezhang Wang, Shanghai, CN;
Yuan Wang, Shanghai, CN;
Xungui He, Shanghai, CN;
Jianping Guo, Shanghai, CN;
Yanling Wang, Shanghai, CN;
Wensheng Tang, Shanghai, CN;
Xingzhong Zhang, Shanghai, CN;
Xuezhang Wang, Shanghai, CN;
Yuan Wang, Shanghai, CN;
2Y-Chem Ltd., Shanghai, CN;
Abstract
The chiral compound S-5-substituted-N-2'-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2′-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5).