The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2013
Filed:
Aug. 14, 2008
David John Moody, Fife, GB;
Jonathan William Wiffen, Craigavon, GB;
David John Moody, Fife, GB;
Jonathan William Wiffen, Craigavon, GB;
Redx Pharma Limited, Manchester, GB;
Abstract
There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein Rrepresents a hydrogen or a hydrocarbyl group, Rrepresents a hydrogen or substituent group, Rrepresents a hydrogen or a hydrocarbyl group, and X represents a hydrogen or substituent group which comprises a) cyanating a compound of formula (1): wherein Y represents a halo group, preferably CI or Br; Prepresents hydrogen or a protecting group, and W represents ═O or —OP, in which Prepresents hydrogen or a protecting group, to give a compound of formula (2): b) reducing the compound of formula (2) to give a compound of formula (3): coupling the compound of formula (3) with a compound of formula (4): to give a compound of formula (5): when W represents —OP, deprotecting and then oxidizing the compound of formula (5) to give a compound of formula (6): and e) subjecting the compound of formula (5) when W represents ═O, or compound of formula (6) to ring-opening, and removal of any remaining protecting groups, to give a compound of formula (7) or salts thereof.