The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2013
Filed:
Apr. 24, 2009
Shankar Kumar, Pleasanton, CA (US);
J. Yun Tso, Menlo Park, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
Shigeyuki Kon, Hokkaido, JP;
Toshimitsu Uede, Hokkaido, JP;
Shankar Kumar, Pleasanton, CA (US);
J. Yun Tso, Menlo Park, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
Shigeyuki Kon, Hokkaido, JP;
Toshimitsu Uede, Hokkaido, JP;
Gene Techno Science Co., Ltd., Hokkaido, JP;
Abstract
The present invention provides humanized antibodies that immunospecifically recognize the RGD sequence. Some of these antibodies inhibit the biological functions of the RGD proteins, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with RGD proteins, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, endometriosis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.