The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2013
Filed:
Dec. 10, 2009
Avinash Phadke, Branford, CT (US);
Dawei Chen, Middletown, CT (US);
Venkat Gadhachanda, Hamden, CT (US);
Akihiro Hashimoto, Branford, CT (US);
Godwin Pais, Hamden, CT (US);
Xiangzhu Wang, Madison, CT (US);
Atul Agarwal, Hamden, CT (US);
Ha Young Kim, Cheshire, CT (US);
Shouming LI, Cheshire, CT (US);
Cuixian Liu, Madison, CT (US);
Suoming Zhang, Palo Alto, CA (US);
Milind Deshpande, Madison, CT (US);
Avinash Phadke, Branford, CT (US);
Dawei Chen, Middletown, CT (US);
Venkat Gadhachanda, Hamden, CT (US);
Akihiro Hashimoto, Branford, CT (US);
Godwin Pais, Hamden, CT (US);
Xiangzhu Wang, Madison, CT (US);
Atul Agarwal, Hamden, CT (US);
Ha Young Kim, Cheshire, CT (US);
Shouming Li, Cheshire, CT (US);
Cuixian Liu, Madison, CT (US);
Suoming Zhang, Palo Alto, CA (US);
Milind Deshpande, Madison, CT (US);
Achillion Pharmaceuticals, Inc., New Haven, CT (US);
Abstract
The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R, R-R, R, R, R, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.