The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 24, 2013
Filed:
Feb. 28, 2012
Lynn Macdonald, White Plains, NY (US);
Richard Torres, New York, NY (US);
Marc R. Morra, Beacon Falls, CT (US);
Joel H. Martin, Putnam Valley, NY (US);
Joel C. Reinhardt, Mount Kisco, NY (US);
Lynn MacDonald, White Plains, NY (US);
Richard Torres, New York, NY (US);
Marc R. Morra, Beacon Falls, CT (US);
Joel H. Martin, Putnam Valley, NY (US);
Joel C. Reinhardt, Mount Kisco, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with Kof 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.