The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
Mar. 05, 2009
Mahabalarao Sampath Kumar Halmuthur, Jammu Tawi, IN;
Ajit Kumar Saxena, Jammu Tawi, IN;
Subhash Chandra Taneja, Jammu Tawi, IN;
Shashank Kumar Singh, Jammu Tawi, IN;
Vijay Kumar Sethi, Jammu Tawi, IN;
Naveed Ahmed Qazi, Jammu Tawi, IN;
Sanghapal Damodhar Sawant, Jammu Tawi, IN;
Mahendhar Reddy Doma, Jammu Tawi, IN;
Abid Hussain Banday, Jammu Tawi, IN;
Monika Verma, Jammu Tawi, IN;
Ghularn Nabi Qazi, Jammu Tawi, IN;
Mahabalarao Sampath Kumar Halmuthur, Jammu Tawi, IN;
Ajit Kumar Saxena, Jammu Tawi, IN;
Subhash Chandra Taneja, Jammu Tawi, IN;
Shashank Kumar Singh, Jammu Tawi, IN;
Vijay Kumar Sethi, Jammu Tawi, IN;
Naveed Ahmed Qazi, Jammu Tawi, IN;
Sanghapal Damodhar Sawant, Jammu Tawi, IN;
Mahendhar Reddy Doma, Jammu Tawi, IN;
Abid Hussain Banday, Jammu Tawi, IN;
Monika Verma, Jammu Tawi, IN;
Ghularn Nabi Qazi, Jammu Tawi, IN;
Council of Scientific & Industrial Research, New Delhi, IN;
Abstract
The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (α-methylene-γ-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 μM to 93 μM. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the α,β-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.