The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
Jun. 24, 2011
Ravindra K. Pandey, E. Amherst, NY (US);
Heinz Baumann, Buffalo, NY (US);
Yihui Chen, Amherst, NY (US);
Penny Joshi, Amherst, NY (US);
Nayan Patel, Buffalo, NY (US);
Ravindra K. Pandey, E. Amherst, NY (US);
Heinz Baumann, Buffalo, NY (US);
Yihui Chen, Amherst, NY (US);
Penny Joshi, Amherst, NY (US);
Nayan Patel, Buffalo, NY (US);
Health Research, Inc., Buffalo, NY (US);
Abstract
A compound in the form of a metallized tetrpyrollic photosensizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emmitance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.