The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
May. 17, 2004
Aimee L. Jackson, Seattle, WA (US);
Steven R. Bartz, Seattle, WA (US);
Julja Burchard, Mount Vernon, WA (US);
Janell M. Schelter, Bellevue, WA (US);
Peter S. Linsley, Seattle, WA (US);
Aimee L. Jackson, Seattle, WA (US);
Steven R. Bartz, Seattle, WA (US);
Julja Burchard, Mount Vernon, WA (US);
Janell M. Schelter, Bellevue, WA (US);
Peter S. Linsley, Seattle, WA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention provides methods and compositions for gene silencing by RNA interference. In particular, the invention provides methods for gene silencing or RNA knockdown using small interfering RNAs (siRNAs) having partial sequence homology to its target gene. The invention also provides methods for identifying common and/or differential responses to a plurality of different siRNAs targeting a gene. The invention also provides methods for evaluating the relative activity of the two strands of an siRNA. The invention further provides methods of designing siRNAs for gene silencing. The invention further provides methods of using siRNAs as therapeutics for treatment of diseases.