The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
Mar. 20, 2008
Jeffrey N. Agar, Newton, MA (US);
Gregory A. Petsko, Belmont, MA (US);
Dagmar Ringe, Belmont, MA (US);
Walter R. P. Novak, Waltham, MA (US);
Jeffrey N. Agar, Newton, MA (US);
Gregory A. Petsko, Belmont, MA (US);
Dagmar Ringe, Belmont, MA (US);
Walter R. P. Novak, Waltham, MA (US);
Brandeis University, Waltham, MA (US);
Abstract
One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease.