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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8609610 B1

PDFFull Text
Expired
Date of Patent:
Dec. 17, 2013

Filed:

Dec. 21, 2012

Inhibitors of the trypsin-like site of the proteasome and methods of use thereof

Applicants:

Trustees of Dartmouth College, Hanover, NH (US);

Leiden University, Leiden, NL;

Inventors:

Alexei Kisselev, West Lebanon, NH (US);

Dmitry V. Filippov, Leiden, NL;

Herman Overkleeft, Leiden, NL;

Assignees:

Trustees of Dartmouth College, Hanover, NH (US);

Leiden University, , NL;

Attorney:

Licata & Tyrrell, P.C.

Primary Examiner:

Cecilia J Tsang

Assistant Examiner:

Zachary J Miknis

Int. Cl.
CPC ...
A61P 33/00 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61K 38/55 (2006.01); C07K 14/81 (2006.01); A61K 38/04 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.

Find Patent Forward Citations

Kisselev, Alexei. (2013). Inhibitors of the trypsin-like site of the proteasome and methods of use thereof (U.S. Patent No. 8609610). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8609610

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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