The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 17, 2013

Filed:

Feb. 02, 2009
Applicants:

Jeroen Kortsmit, Cape Town, ZA;

Niels Jozef Bart Driessen, Rosmalen, NL;

Marcel Cornelis Maria Rutten, Eindhoven, NL;

Franciscus Petrus Thomas Baaijens, Eindhoven, NL;

Inventors:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/07 (2010.01); A61F 2/00 (2006.01); A01N 1/02 (2006.01); C12Q 1/02 (2006.01); C12N 11/00 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within the bioreactor chamber for developing the cell-seeded scaffold to a tissue structure and next to the tissue construct, applying a dynamic pressure difference to the developing tissue structure by the flow of nutrient medium to induce dynamic strain on the tissue structure.


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