The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
Nov. 03, 2004
Shite Sebastian, Somerville, MA (US);
Gerard J. Colpas, Holden, MA (US);
Diane L. Ellis-busby, Lancaster, MA (US);
Jennifer M. Havard, Framingham, MA (US);
Mitchell C. Sanders, West Boylston, MA (US);
Shite Sebastian, Somerville, MA (US);
Gerard J. Colpas, Holden, MA (US);
Diane L. Ellis-Busby, Lancaster, MA (US);
Jennifer M. Havard, Framingham, MA (US);
Mitchell C. Sanders, West Boylston, MA (US);
Systagenix Wound Management (US), Inc., Wilmington, DE (US);
Abstract
Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α 1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.