The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
May. 02, 2011
Radoje Drmanac, Los Altos Hills, CA (US);
Matthew J. Callow, Redwood City, CA (US);
Brian K. Hauser, Campbell, CA (US);
George Yeung, Mountain View, CA (US);
Radoje Drmanac, Los Altos Hills, CA (US);
Matthew J. Callow, Redwood City, CA (US);
Brian K. Hauser, Campbell, CA (US);
George Yeung, Mountain View, CA (US);
Callida Genomics, Inc., Sunnyvale, CA (US);
Abstract
The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are 'self-assembled' in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences.