The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 17, 2013
Filed:
Jun. 01, 2010
Vega Masignani, Siena, IT;
Michele Anne Barocchi, Florence, IT;
Monica Moschioni, Cose Val D'Elsa, IT;
Paolo Ruggiero, Rapolano Terme, IT;
Vega Masignani, Siena, IT;
Michele Anne Barocchi, Florence, IT;
Monica Moschioni, Cose Val D'Elsa, IT;
Paolo Ruggiero, Rapolano Terme, IT;
Novartis AG, Basel, CH;
Abstract
Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.