The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Dec. 04, 2009
Calum John Drummond, Victoria, AU;
Sharon Marie Sagnella, New South Wales, AU;
Minoo Jalili Moghaddam, New South Wales, AU;
Xiaojuan Gong, New South Wales, AU;
Calum John Drummond, Victoria, AU;
Sharon Marie Sagnella, New South Wales, AU;
Minoo Jalili Moghaddam, New South Wales, AU;
Xiaojuan Gong, New South Wales, AU;
Commonwealth Scientific and Industrial Research Organisation, Austrailian Capital Territory, AU;
Abstract
Amphiphilic prodrugs of general formula A-X are disclosed, wherein A is a biologically active agent or may be metabolised to a biologically active agent; and X is selected from the group consisting of R, or up to three R moieties attached to a linker, Y, Yor Y, wherein R is selected from a group consisting of alkyl, alkenyl, alkynyl, branched alkyl, branched alkenyl, branched alkynyl, substituted alkyl, substituted alkenyl and substituted alkynyl groups and their analogues; Yis a linker group which covalently attached to an R group at one site and is attached to A at a further independent site; Yis a linker group which is covalently attached to two R groups at two independent sites and is attached to A at a further independent site; and Yis a linker group which is covalently attached to three R groups at three independent sites and is attached to A at a further independent site. Self-assembly of the amphiphilic prodrugs into reverse lyotropic phases, particularly hexagonal, cubic and sponge, is disclosed. In preferred embodiments A is dopamine or a 5-fluorouracil prodrug.