The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Nov. 05, 2008
Timothy J. Guzi, Sudbury, MA (US);
David A. Parry, Mountain View, CA (US);
Marc A. Labroli, Moorestown, NJ (US);
Michael D. Dwyer, Scotch Plains, NJ (US);
Kamil Paruch, Tisnov, CZ;
Timothy J. Guzi, Sudbury, MA (US);
David A. Parry, Mountain View, CA (US);
Marc A. Labroli, Moorestown, NJ (US);
Michael D. Dwyer, Scotch Plains, NJ (US);
Kamil Paruch, Tisnov, CZ;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.