The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Nov. 17, 2006
David Shanahan, Dallas, TX (US);
John Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Dallas, TX (US);
Phillip Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
David Shanahan, Dallas, TX (US);
John Nemunaitis, Cedar Hill, TX (US);
Neil Senzer, Dallas, TX (US);
Phillip Maples, Pilot Point, TX (US);
Donald Rao, Dallas, TX (US);
Gradalis, Inc., Carrollton, TX (US);
Abstract
Methods for treating cancer that include (a) obtaining a specimen of cancer issue from a patient; (b) obtaining a specimen of normal tissue in the proximity of the cancer tissue; (c) extracting total protein from the cancer tissue and normal tissue; (d) obtaining a protein expression profile of the cancer tissue and normal tissue; (e) identifying a group of proteins that are expressed in the cancer tissue at significantly different levels than in the normal tissue; (f) identifying one or more prioritized proteins from the group of proteins, which will serve as the target for an RNA interference molecule (RNAi), which, when provided to a patient, will reduce the expression level of the one or more prioritized proteins using both cleavage-dependent and cleavage-independent pathways of the RNA-induced silencing complex (RISC).