The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Feb. 11, 2005
Odile Esther Levy, San Diego, CA (US);
Carolyn M. Jodka, Encinitas, CA (US);
Soumitra S. Ghosh, San Diego, CA (US);
David G. Parkes, Del Mar, CA (US);
Richard A. Pittner, San Diego, CA (US);
Lawrence J. D'souza, San Diego, CA (US);
John S. Ahn, San Diego, CA (US);
Kathryn S. Prickett, San Diego, CA (US);
Odile Esther Levy, San Diego, CA (US);
Carolyn M. Jodka, Encinitas, CA (US);
Soumitra S. Ghosh, San Diego, CA (US);
David G. Parkes, Del Mar, CA (US);
Richard A. Pittner, San Diego, CA (US);
Lawrence J. D'Souza, San Diego, CA (US);
John S. Ahn, San Diego, CA (US);
Kathryn S. Prickett, San Diego, CA (US);
Amylin Pharmaceuticals, LLC, San Diego, CA (US);
AstraZeneca Pharmaceuticals LP, Wilmington, DE (US);
Abstract
The present invention relates to novel Pancreatic Polypeptide Family ('PPF') polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50% sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.