The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Jan. 25, 2011
Applicants:
Daisuke Yamaguchi, Kanagawa, JP;
Seiji Yamada, Kanagawa, JP;
Yoshio Goto, Kanagawa, JP;
Yuichi Tokita, Kanagawa, JP;
Inventors:
Daisuke Yamaguchi, Kanagawa, JP;
Seiji Yamada, Kanagawa, JP;
Yoshio Goto, Kanagawa, JP;
Yuichi Tokita, Kanagawa, JP;
Assignee:
Sony Corporation, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 9/04 (2006.01); C12N 1/20 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C12Q 1/68 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to become smaller than that of a wild type enzyme through deletion, replacement, addition, or insertion of one or several amino acids in the amino acid sequence of the wild type enzyme with respect to tyrosine-dependent short-chain dehydrogenase/reductase.