The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Nov. 30, 2005
Qiming Chen, Collegeville, PA (US);
Mohit Trikha, San Mateo, CA (US);
Robert J. Lutz, Wayland, MA (US);
Rita M. Steeves, Stoneham, MA (US);
Godfrey Amphlett, Cambridge, MA (US);
Qiming Chen, Collegeville, PA (US);
Mohit Trikha, San Mateo, CA (US);
Robert J. Lutz, Wayland, MA (US);
Rita M. Steeves, Stoneham, MA (US);
Godfrey Amphlett, Cambridge, MA (US);
Janssen Biotech, Inc., Radnor, PA (US);
Immunogen, Inc., Cambridge, MA (US);
Abstract
The invention relates to conjugates of anti-integrin specific antibodies with cytotoxic compounds, the synthesis, selection, and use of such conjugates for use in cancer therapy or other diseases mediated by cell proliferation, cell migration, or inflammation and which pathology involves angiogenesis or neovascularization of new tissue. In addition the invention relates to combination therapy of such diseases wherein the treatment comprises use of said conjugates in combination with one or more other treatment modalities including but not limited to: chemotherapy, surgery or radiation therapy. The preferred conjugates contain maytansinoid compounds linked to the antibody by a disulfide linkage, and preferred chemotherapeutic agents are doxorubicin, a taxane, a camptothecin, a podophyllotoxin, a nucleoside analog, or a pyrimidine analog.