The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 10, 2013
Filed:
Apr. 09, 2008
Scott Glaser, San Diego, CA (US);
Mitchell Reff, San Diego, CA (US);
Tzung-horng Yang, San Diego, CA (US);
Xiufeng Wu, San Diego, CA (US);
Paul Chinn, Carlsbad, CA (US);
Scott Glaser, San Diego, CA (US);
Mitchell Reff, San Diego, CA (US);
Tzung-Horng Yang, San Diego, CA (US);
Xiufeng Wu, San Diego, CA (US);
Paul Chinn, Carlsbad, CA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.