The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2013
Filed:
Nov. 16, 2007
Computer systems and methods for identifying conserved cellular constituent clusters across datasets
Serguei Stepaniants, Redmond, WA (US);
Pek Y. Lum, Seattle, WA (US);
Roy Kuraisa, Seattle, WA (US);
Eric E. Schadt, Kirkland, WA (US);
Serguei Stepaniants, Redmond, WA (US);
Pek Y. Lum, Seattle, WA (US);
Roy Kuraisa, Seattle, WA (US);
Eric E. Schadt, Kirkland, WA (US);
Microsoft Corporation, Redmond, WA (US);
Abstract
Systems and methods for determining a functional relationship between pairs of cellular constituents are provided. A plurality of datasets is received. Each dataset represents an experimental condition and comprises measurement data for a plurality of cellular constituents from each of a plurality of organisms. Each respective dataset is represented by correlation coefficients. Each correlation coefficient for a respective dataset in the plurality of datasets represents a correlation between abundance measurement data for a pair of cellular constituents across the dataset. The plurality of correlation coefficients that represents a first dataset in the plurality of datasets is clustered, thereby determining their order. This order is applied to each remaining dataset thereby forming a plurality of correlation matrices. When a conserved area in the plurality of matrices is identified, the functional relationship between the first cellular constituent and the second constituent is determined to be present.