The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2013
Filed:
Mar. 23, 2011
Jeffrey Michael Axten, Collegeville, PA (US);
Seth Wilson Grant, Collegeville, PA (US);
Dirk A. Heerding, Collegeville, PA (US);
Jesus Rual Medina, Collegeville, PA (US);
Stuart Paul Romeril, Collegeville, PA (US);
Jun Tang, Research Triangle Park, NC (US);
Jeffrey Michael Axten, Collegeville, PA (US);
Seth Wilson Grant, Collegeville, PA (US);
Dirk A. Heerding, Collegeville, PA (US);
Jesus Rual Medina, Collegeville, PA (US);
Stuart Paul Romeril, Collegeville, PA (US);
Jun Tang, Research Triangle Park, NC (US);
GlaxoSmithKline LLC, Philadelphia, PA (US);
Abstract
The invention is directed to substituted indoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R, R, and Rare defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, stroke, Type 1 diabetes Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.