The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2013
Filed:
May. 12, 2010
Andrew G. Myers, Boston, MA (US);
Mark G. Charest, Belle Mead, NJ (US);
Christian D. Lerner, Binningen, CH;
Jason D. Brubaker, Cheshire, CT (US);
Dionicio R. Siegel, New York, NY (US);
Andrew G. Myers, Boston, MA (US);
Mark G. Charest, Belle Mead, NJ (US);
Christian D. Lerner, Binningen, CH;
Jason D. Brubaker, Cheshire, CT (US);
Dionicio R. Siegel, New York, NY (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.