The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2013
Filed:
May. 26, 2009
Bennard Van Ravenzwaay, Altrip, DE;
Werner Mellert, Haβloch, DE;
Georgia Coelho Palermo Cunha, Sao Paulo, BR;
Eric Fabian, Ludwigshafen, DE;
Volker Strauss, Bad Dürkheim, DE;
Hennicke Kamp, Bischheim, DE;
Tilmann B. Walk, Kleinmachnow, DE;
Ralf Looser, Berlin, DE;
Michael Manfred Herold, Berlin, DE;
Jan C Wiemer, Berlin, DE;
Alexandre Prokoudine, Berlin, DE;
Edgar Leibold, Carlsberg, DE;
Bennard van Ravenzwaay, Altrip, DE;
Werner Mellert, Haβloch, DE;
Georgia Coelho Palermo Cunha, Sao Paulo, BR;
Eric Fabian, Ludwigshafen, DE;
Volker Strauss, Bad Dürkheim, DE;
Hennicke Kamp, Bischheim, DE;
Tilmann B. Walk, Kleinmachnow, DE;
Ralf Looser, Berlin, DE;
Michael Manfred Herold, Berlin, DE;
Jan C Wiemer, Berlin, DE;
Alexandre Prokoudine, Berlin, DE;
Edgar Leibold, Carlsberg, DE;
BASF SE, , DE;
Abstract
The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.