The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
Oct. 16, 2009
Philip Wilson Howard, London, GB;
Stephen John Gregson, London, GB;
Luke Masterson, London, GB;
Spirogen Sarl, St-Legier-la Chiesaz, CH;
Abstract
Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables Rand Rrepresent. Formula (I), wherein: Ris of formula (II), where A is a Caryl group, X is selected from the group comprising: OH, SH, COH, COH, N═C═O, NHR, wherein Ris selected from the group comprising H and Calkyl, and (OCH)OCH, where m is 1 to 3, and either: (i) Qis a single bond, and Qis selected from a single bond and —Z—(CH)—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Qis —CH═CH—, and Qis a single bond; Ris a Caryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, Calkyl, Cheterocyclyl and bis-oxy-Calkylene. The other variables are as defined in the claims. The compounds are useful for the treatment of proliferative diseases.