The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 2013
Filed:
May. 31, 2007
Tomokatsu Iwamura, Kanagawa, JP;
Hideki Narumi, Kanagawa, JP;
Hajime Masumoto, Kanagawa, JP;
Akihito Kaneda, Kanagawa, JP;
Akiko Soneda, Kanagawa, JP;
Shizuo Akira, Osaka, JP;
Tomokatsu Iwamura, Kanagawa, JP;
Hideki Narumi, Kanagawa, JP;
Hajime Masumoto, Kanagawa, JP;
Akihito Kaneda, Kanagawa, JP;
Akiko Soneda, Kanagawa, JP;
Shizuo Akira, Osaka, JP;
Toray Industries, Inc., Tokyo, JP;
Osaka University, Suita-Shi, JP;
Abstract
A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an application thereof are provided. That is, the present invention provides the immunostimulatory oligonucleotide composed of a base sequence represented by a formula: 5'-(G)PXCGYQ(G)-3′ (SEQ ID NO: 118) (X and Y are mutually independent and represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive G residues, and a length of X+Y is 6 to 20 nucleotides; XCGY contains a palindrome sequence having a length of at least 8 nucleotides and has a length of 8 to 22 nucleotides; P and Q are mutually independent and represent one nucleotide other than G; M represents an integer of 6 to 10 and N represents an integer of 0 to 3) wherein a full length thereof is 16 to 37 nucleotides (except for an oligonucleotide composed of a base sequence represented by SEQ ID NO:5), the pharmaceutical application thereof.